Abstract
CD4C/HIVNef Tg mice express HIV-1 Nef in relevant target cells through the regulatory sequences of the human CD4 gene. These mice develop a severe disease showing many characteristics of human AIDS. A summary of the results obtained with these Tg mice is presented.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Acquired Immunodeficiency Syndrome / genetics
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Acquired Immunodeficiency Syndrome / immunology*
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Animals
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CD4-Positive T-Lymphocytes / immunology*
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Disease Models, Animal*
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HIV-1 / genetics*
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Mice
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Mice, Transgenic*
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Phenotype
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nef Gene Products, Human Immunodeficiency Virus / physiology*
Substances
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nef Gene Products, Human Immunodeficiency Virus