The CD4C/HIV(Nef)transgenic model of AIDS

Curr HIV Res. 2011 Oct;9(7):524-30. doi: 10.2174/157016211798842062.

Abstract

CD4C/HIVNef Tg mice express HIV-1 Nef in relevant target cells through the regulatory sequences of the human CD4 gene. These mice develop a severe disease showing many characteristics of human AIDS. A summary of the results obtained with these Tg mice is presented.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acquired Immunodeficiency Syndrome / genetics
  • Acquired Immunodeficiency Syndrome / immunology*
  • Animals
  • CD4-Positive T-Lymphocytes / immunology*
  • Disease Models, Animal*
  • HIV-1 / genetics*
  • Mice
  • Mice, Transgenic*
  • Phenotype
  • nef Gene Products, Human Immunodeficiency Virus / physiology*

Substances

  • nef Gene Products, Human Immunodeficiency Virus