Methylation pattern of the putative tumor-suppressor gene LRRC3B promoter in clear cell renal cell carcinomas

A G Kondratov; L A Stoliar; S M Kvasha; V V Gordiyuk; Y M Zgonnyk; A V Gerashchenko; A F Vozianov; A V Rynditch; E R Zabarovsky; V I Kashuba

doi:10.3892/mmr.2011.681

Methylation pattern of the putative tumor-suppressor gene LRRC3B promoter in clear cell renal cell carcinomas

Mol Med Rep. 2012 Feb;5(2):509-12. doi: 10.3892/mmr.2011.681. Epub 2011 Nov 16.

Authors

A G Kondratov¹, L A Stoliar, S M Kvasha, V V Gordiyuk, Y M Zgonnyk, A V Gerashchenko, A F Vozianov, A V Rynditch, E R Zabarovsky, V I Kashuba

Affiliation

¹ Department of Molecular Oncogenetics, Institute of Molecular Biology and Genetics, 03143 Kiev, Ukraine. o.g.kondratov@imbg.org.ua

PMID: 22101383
DOI: 10.3892/mmr.2011.681

Abstract

The leucine rich repeat containing 3B (LRRC3B) gene is a putative tumor suppressor located on human chromosome 3 in the 3p24 region. LRRC3B is frequently altered in colon and gastric cancers and also in leukaemias. In this study we investigated the promoter region methylation as a possible mechanism of LRRC3B gene inactivation in clear cell renal cell carcinomas. We found that the LRRC3B gene promoter was methylated in 43% of clear cell renal carcinoma samples. However, no correlation between DNA methylation and LRRC3B expression was found.

Keywords: DNA methylation; clear cell renal cell carcinoma; tumor-suppressor gene.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Carcinoma, Renal Cell / genetics*
Carcinoma, Renal Cell / physiopathology*
DNA Methylation*
Humans
Kidney Neoplasms / genetics*
Neoplasm Proteins / genetics*
Neoplasm Proteins / metabolism*
Neoplasm Staging
Promoter Regions, Genetic*

Substances

LRRC3B protein, human
Neoplasm Proteins