aza-Flavanones as potent cross-species microRNA inhibitors that arrest cell cycle

Srivari Chandrasekhar; Sreerangam N C V L Pushpavalli; Srinivas Chatla; Debasmita Mukhopadhyay; Bogonda Ganganna; Kandi Vijeender; Pabbaraja Srihari; Chada Raji Reddy; M Janaki Ramaiah; Utpal Bhadra

doi:10.1016/j.bmcl.2011.10.061

aza-Flavanones as potent cross-species microRNA inhibitors that arrest cell cycle

Bioorg Med Chem Lett. 2012 Jan 1;22(1):645-8. doi: 10.1016/j.bmcl.2011.10.061. Epub 2011 Oct 24.

Authors

Srivari Chandrasekhar¹, Sreerangam N C V L Pushpavalli, Srinivas Chatla, Debasmita Mukhopadhyay, Bogonda Ganganna, Kandi Vijeender, Pabbaraja Srihari, Chada Raji Reddy, M Janaki Ramaiah, Utpal Bhadra

Affiliation

¹ Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 607, India. srivaric@iict.res.in

PMID: 22100313
DOI: 10.1016/j.bmcl.2011.10.061

Abstract

aza-Flavanones have been identified as a new class of selective microRNA inhibitors. These compounds were found to arrest cell cycle via a novel cross species microRNA-dependent regulatory pathway interpreting an unexpected link between cell cycle arrest and microRNA mediated control in cancer.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / pharmacology
Apoptosis
Cell Cycle / drug effects*
Cell Line, Tumor
Chemistry, Pharmaceutical / methods*
Drosophila melanogaster / metabolism*
Drug Design
Flavanones / chemistry
Flavanones / pharmacology*
Green Fluorescent Proteins / metabolism
HeLa Cells
Humans
MicroRNAs / metabolism*
Models, Biological
Models, Chemical
Neoplasms / drug therapy*
Species Specificity

Substances

Antineoplastic Agents
Flavanones
MicroRNAs
Green Fluorescent Proteins