Synthesis of 5-aryl-1,4-benzodiazepine derivatives attached in resorcinaren-PAMAM dendrimers and their anti-cancer activity

Sandra Cortez-Maya; Simón Hernández-Ortega; Teresa Ramírez-Apan; Irina V Lijanova; Marcos Martínez-García

doi:10.1016/j.bmc.2011.10.070

Synthesis of 5-aryl-1,4-benzodiazepine derivatives attached in resorcinaren-PAMAM dendrimers and their anti-cancer activity

Bioorg Med Chem. 2012 Jan 1;20(1):415-21. doi: 10.1016/j.bmc.2011.10.070. Epub 2011 Oct 31.

Authors

Sandra Cortez-Maya¹, Simón Hernández-Ortega, Teresa Ramírez-Apan, Irina V Lijanova, Marcos Martínez-García

Affiliation

¹ Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Circuito Exterior, Coyoacán, C.P. 04510, México D.F., Mexico.

PMID: 22099256
DOI: 10.1016/j.bmc.2011.10.070

Abstract

A series of resorcinaren-PAMAM dendrimers with benzodiazepines in the periphery were synthesized and their anticancer properties studied. The synthesized dendrimers showed potential anticancer activities, which were enhanced in the presence of a chloro-substituent in the second ring of the 5-aryl-1,4-benzodiazepine. The dendrimers were characterized by IR, (1)H and (13)C NMR, UV-vis absorption, electrospray (ES) and/or MALDI-TOF mass spectrometries.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Benzodiazepines / chemical synthesis
Benzodiazepines / chemistry*
Benzodiazepines / pharmacology*
Calixarenes / chemistry*
Cell Line, Tumor
Crystallography, X-Ray
Dendrimers / chemistry*
Drug Screening Assays, Antitumor
Humans
Molecular Conformation
Phenylalanine / analogs & derivatives*
Phenylalanine / chemistry

Substances

Antineoplastic Agents
Dendrimers
PAMAM Starburst
resorcinarene
Benzodiazepines
Calixarenes
Phenylalanine