In order to explore the pathogenesis of ischemic cerebrovascular disease, drug screening, efficacy evaluation and treatment plan optimization, many kinds of animal models against ischemic cerrebrocardiac were established with operation successively in recent years. According to the characteristic of traditional Chinese medicine, it's a question to choose the appropriate animal model for drug screening and efficacy evaluation, and to combine the cerebral ischemia of animal models with clinical disease research closely. The stability and reliability of animal models and the efficacy of drugs in clinical should be considered in order to provide effective drug screening evaluation research tools.