One-pot synthesis of novel 2,3-dihydro-1H-indazoles

Molecules. 2011 Nov 16;16(11):9553-61. doi: 10.3390/molecules16119553.

Abstract

A copper(I)-mediated one-pot synthesis of 2,3-dihydro-1H-indazole heterocycles has been developed. This synthetic route provides the desired indazoles in moderate to good yields (55%-72%) which are substantially better than those achievable with an alternative two-step reaction sequence. The reaction is tolerant of functionality on the aromatic ring.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bromides / chemistry
  • Copper / chemistry
  • Hydrazines / chemistry
  • Indazoles / chemical synthesis*
  • Indazoles / chemistry*
  • Molecular Structure

Substances

  • Bromides
  • Hydrazines
  • Indazoles
  • Copper