Abstract
The methoxy substitued two novel bis triazole-schiff bases (6 a-b) were synthesized with 4-amino-3,5-diethyl-4H-1,2,4-triazole and various bis-aldehydes. Their amine derivatives prepared by reduced with NaBH(4) (5 a-b). The obtained products 6 a-b and 7 a-b were identified by FT-IR, (1)H-NMR, (13)C-NMR. The bis triazole-schiff bases and amine derivatives were tested for antimicrobial activity using the agar diffusion technique against 11 bacteria. The synthesized compounds (6 a-b and 7 a-b) were screened for their antielastase, antiurease and antioxidant activities. The resuts showed that the synthesized compounds (6 a-b and 7 a-b) had effective antielastase and antiurease activities.
MeSH terms
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Antioxidants / chemical synthesis*
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Antioxidants / chemistry
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Antioxidants / pharmacology*
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Chemistry Techniques, Synthetic
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Dose-Response Relationship, Drug
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Drug Evaluation, Preclinical
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Enzyme Inhibitors / chemical synthesis
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology*
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Inhibitory Concentration 50
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Pancreatic Elastase / antagonists & inhibitors*
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Pancreatic Elastase / metabolism
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Schiff Bases / chemistry
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Spectroscopy, Fourier Transform Infrared
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Structure-Activity Relationship
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Triazoles / chemistry*
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Urease / antagonists & inhibitors*
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Urease / metabolism
Substances
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Anti-Bacterial Agents
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Antioxidants
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Enzyme Inhibitors
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Schiff Bases
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Triazoles
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1,2,4-triazole
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Pancreatic Elastase
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Urease