(99m)TC-octreotide scintigraphy and somatostatin receptor subtype expression in juvenile nasopharyngeal angiofibromas

Head Neck. 2011 Dec;33(12):1739-46. doi: 10.1002/hed.21668. Epub 2011 Jan 10.

Abstract

Background: The main goal of the study was the analysis of somatostatin receptor (SSTR) expression on juvenile nasopharyngeal angiofibroma (JNA) cells and a subsequent analysis of the utility of SST analog-based scintigraphy in JNA diagnostics.

Methods: Nine JNA cases were analyzed. All tissue samples were analyzed for the expression of SSTRs. In 2 cases, scintigraphy was performed after the intravenous (IV) administration of an SST analog. MRI of the craniofacial region was subsequently performed.

Results: The SST analogues were accumulated in areas matching pathologic tissue in the nasopharynx. Immunohistochemical evaluation of the tissue samples proved the overexpression of SSTRs.

Conclusions: SSTRs are overexpressed on JNA cells. The SST analog (99m)TC-octreotide is effectively bound to JNA cells. SST analogues might be used in the diagnostics and treatment of primary, recurrent, or residual JNA.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Angiofibroma / diagnosis
  • Angiofibroma / diagnostic imaging*
  • Angiofibroma / metabolism
  • Humans
  • Immunohistochemistry
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Nasopharyngeal Neoplasms / diagnosis
  • Nasopharyngeal Neoplasms / diagnostic imaging*
  • Nasopharyngeal Neoplasms / metabolism
  • Octreotide / analogs & derivatives
  • Organotechnetium Compounds
  • Radionuclide Imaging
  • Radiopharmaceuticals
  • Receptors, Somatostatin / classification
  • Receptors, Somatostatin / metabolism*
  • Young Adult

Substances

  • Organotechnetium Compounds
  • Radiopharmaceuticals
  • Receptors, Somatostatin
  • technetium Tc 99m-tricine-hydrazinonicotinyl-Phe(1)-Tyr(3)-octreotide
  • Octreotide