Recent advances in the biology and chemistry of the flavaglines

Nigel Ribeiro; Frédéric Thuaud; Canan Nebigil; Laurent Désaubry

doi:10.1016/j.bmc.2011.10.048

Recent advances in the biology and chemistry of the flavaglines

Bioorg Med Chem. 2012 Mar 15;20(6):1857-64. doi: 10.1016/j.bmc.2011.10.048. Epub 2011 Oct 20.

Authors

Nigel Ribeiro¹, Frédéric Thuaud, Canan Nebigil, Laurent Désaubry

Affiliation

¹ Therapeutic Innovation Laboratory, UMR 7200, CNRS/Université de Strasbourg, 67401 Illkirch, France.

PMID: 22071525
DOI: 10.1016/j.bmc.2011.10.048

Abstract

The flavaglines are a family of plant natural products that induce potent anticancer and neuroprotective activities. This review summarizes recent synthetic approaches to flavaglines and the current status of their pharmacological properties.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Antineoplastic Agents, Phytogenic / chemical synthesis
Antineoplastic Agents, Phytogenic / chemistry*
Antineoplastic Agents, Phytogenic / pharmacology*
Biological Products / chemical synthesis
Biological Products / chemistry*
Biological Products / pharmacology*
Humans
Neoplasms / drug therapy
Neoplasms / metabolism
Plants / chemistry*
Signal Transduction / drug effects

Substances

Antineoplastic Agents, Phytogenic
Biological Products