Growth rate dependence of global amino acid composition

V Emilsson; C G Kurland

doi:10.1016/0167-4781(90)90175-2

Growth rate dependence of global amino acid composition

Biochim Biophys Acta. 1990 Aug 27;1050(1-3):248-51. doi: 10.1016/0167-4781(90)90175-2.

Authors

V Emilsson¹, C G Kurland

Affiliation

¹ Department of Molecular Biology, Biomedicum, Uppsala, Sweden.

PMID: 2207150
DOI: 10.1016/0167-4781(90)90175-2

Abstract

The global amino acid composition of bacteria growing in different media has been studied. The data reveal significant changes in the amino acid composition in the growth rate range between 0.5 and 2.1 doublings per hour at 37 degrees C. The changes are consistent with a progressive simplification of the protein population and mRNA pools as the growth rates increase.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acids / metabolism
Bacterial Proteins / biosynthesis*
Bacterial Proteins / genetics
Escherichia coli / genetics
Escherichia coli / growth & development*
Escherichia coli / metabolism
Kinetics
Protein Biosynthesis*

Substances

Amino Acids
Bacterial Proteins