Objectives: The objective was to investigate the putative associations of specific pesticides with soft-tissue sarcoma (STS).
Methods: A Canadian population-based case-control study conducted in six provinces was used in this analysis. The study design consisted of two stages: a self-administered postal questionnaire and a telephone interview for those reporting pesticides exposure of 10 hours per year or more; and a 15% random sample of the remainder. Conditional logistic regression was used to fit the statistical models.
Results: A positive history of cancer among first-degree relatives and exposure to aldrin and diazinon were statistically significant independent predictors of an increased risk for STS, whereas diagnosis of whopping cough lowered the risk of STS.
Conclusions: The incidence of STS was associated with specific insecticides after adjustment for other independent predictors.