The spiFEG locus in Streptococcus infantarius subsp. infantarius BAA-102 confers protection against nisin U

Antimicrob Agents Chemother. 2012 Jan;56(1):573-8. doi: 10.1128/AAC.05778-11. Epub 2011 Nov 7.

Abstract

Nisin U is a member of the extended nisin family of lantibiotics. Here we identify the presence of nisin U immunity gene homologues in Streptococcus infantarius subsp. infantarius BAA-102. Heterologous expression of these genes in Lactococcus lactis subsp. cremoris HP confers protection to nisin U and other members of the nisin family, thereby establishing that the recently identified phenomenon of resistance through immune mimicry also occurs with respect to nisin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / biosynthesis
  • Bacteriocins / biosynthesis*
  • Bacteriocins / genetics
  • DNA, Bacterial
  • Drug Resistance, Bacterial
  • Escherichia coli
  • Gene Expression
  • Genes, Bacterial
  • Genetic Loci
  • Lactococcus lactis / genetics*
  • Lactococcus lactis / metabolism
  • Molecular Mimicry
  • Nisin / biosynthesis*
  • Nisin / genetics
  • Streptococcus / genetics*
  • Streptococcus / metabolism

Substances

  • Anti-Bacterial Agents
  • Bacteriocins
  • DNA, Bacterial
  • Nisin