Abstract
Nisin U is a member of the extended nisin family of lantibiotics. Here we identify the presence of nisin U immunity gene homologues in Streptococcus infantarius subsp. infantarius BAA-102. Heterologous expression of these genes in Lactococcus lactis subsp. cremoris HP confers protection to nisin U and other members of the nisin family, thereby establishing that the recently identified phenomenon of resistance through immune mimicry also occurs with respect to nisin.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / biosynthesis
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Bacteriocins / biosynthesis*
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Bacteriocins / genetics
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DNA, Bacterial
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Drug Resistance, Bacterial
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Escherichia coli
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Gene Expression
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Genes, Bacterial
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Genetic Loci
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Lactococcus lactis / genetics*
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Lactococcus lactis / metabolism
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Molecular Mimicry
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Nisin / biosynthesis*
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Nisin / genetics
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Streptococcus / genetics*
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Streptococcus / metabolism
Substances
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Anti-Bacterial Agents
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Bacteriocins
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DNA, Bacterial
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Nisin