Hypergravity effects on myoblast proliferation and differentiation

Gianni Ciofani; Leonardo Ricotti; Jacopo Rigosa; Arianna Menciassi; Virgilio Mattoli; Monica Monici

doi:10.1016/j.jbiosc.2011.09.025

Hypergravity effects on myoblast proliferation and differentiation

J Biosci Bioeng. 2012 Feb;113(2):258-61. doi: 10.1016/j.jbiosc.2011.09.025. Epub 2011 Nov 4.

Authors

Gianni Ciofani¹, Leonardo Ricotti, Jacopo Rigosa, Arianna Menciassi, Virgilio Mattoli, Monica Monici

Affiliation

¹ Italian Institute of Technology, Center of MicroBioRobotics c/o Scuola Superiore Sant'Anna, Viale Rinaldo Piaggio 34, 56025 Pontedera (Pisa), Italy. g.ciofani@sssup.it, gianni.ciofani@iit.it

PMID: 22055920
DOI: 10.1016/j.jbiosc.2011.09.025

Abstract

This study aimed at the investigation of behavior of myoblasts in conditions of altered gravity. C2C12 cells underwent stimulations by different hypergravity intensities (2 h at 5 g, 10 g, and 20 g) in the Large Diameter Centrifuge of the European Space Agency (ESA), highlighting positive effects on both proliferation and differentiation.

MeSH terms

Animals
Cell Differentiation
Cell Line
Cell Proliferation
Centrifugation
Hypergravity*
Mice
Muscle Fibers, Skeletal / cytology*