Anti-diabetic potential of ursolic acid stearoyl glucoside: a new triterpenic gycosidic ester from Lantana camara

Imran Kazmi; Mahfoozur Rahman; Muhammad Afzal; Gaurav Gupta; Shakir Saleem; Obaid Afzal; Md Adil Shaharyar; Ujjwal Nautiyal; Sayeed Ahmed; Firoz Anwar

doi:10.1016/j.fitote.2011.10.004

Anti-diabetic potential of ursolic acid stearoyl glucoside: a new triterpenic gycosidic ester from Lantana camara

Fitoterapia. 2012 Jan;83(1):142-6. doi: 10.1016/j.fitote.2011.10.004. Epub 2011 Oct 24.

Authors

Imran Kazmi¹, Mahfoozur Rahman, Muhammad Afzal, Gaurav Gupta, Shakir Saleem, Obaid Afzal, Md Adil Shaharyar, Ujjwal Nautiyal, Sayeed Ahmed, Firoz Anwar

Affiliation

¹ Siddhartha Institute of Pharmacy, Uttarakhand, India.

PMID: 22051701
DOI: 10.1016/j.fitote.2011.10.004

Abstract

A new stearoyl glucoside of ursolic acid, urs-12-en-3β-ol-28-oic acid 3β-D-glucopyranosyl-4'-octadecanoate and other compounds were isolated from the leaves of Lantana camara L. The structure of this new glycoside was elucidated and established by standard spectroscopic methods. In streptozotocin-induced diabetic rats it showed significant reduction in blood glucose level.

MeSH terms

Animals
Blood Glucose / drug effects
Diabetes Mellitus, Experimental / drug therapy*
Glucosides / chemistry
Glucosides / pharmacology*
Hypoglycemic Agents / chemistry
Hypoglycemic Agents / pharmacology*
Lantana / chemistry*
Molecular Structure
Plant Leaves / chemistry
Rats
Sterols / chemistry
Sterols / pharmacology*
Triterpenes / chemistry
Triterpenes / pharmacology*
Ursolic Acid

Substances

Blood Glucose
Glucosides
Hypoglycemic Agents
Sterols
Triterpenes