Eu(II)-containing cryptates as contrast agents for ultra-high field strength magnetic resonance imaging

Chem Commun (Camb). 2011 Dec 28;47(48):12858-60. doi: 10.1039/c1cc15219j. Epub 2011 Nov 2.

Abstract

The relaxivity (contrast-enhancing ability) of Eu(II)-containing cryptates was found to be better than a clinically approved Gd(III)-based agent at 7 T. These cryptates are among a few examples of paramagnetic substances that show an increase in longitudinal relaxivity, r(1), at ultra-high field strength relative to lower field strengths.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Contrast Media / chemistry*
  • Coordination Complexes / chemistry
  • Crown Ethers / chemistry*
  • Europium / chemistry*
  • Heterocyclic Compounds, 1-Ring / chemistry
  • Magnetic Resonance Imaging*
  • Magnetics

Substances

  • Contrast Media
  • Coordination Complexes
  • Crown Ethers
  • Heterocyclic Compounds, 1-Ring
  • 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid
  • Europium