Cranberry as promising natural source of potential anticancer agents: current evidence and future perspectives

Anticancer Agents Med Chem. 2012 Jul;12(6):619-30. doi: 10.2174/187152012800617669.

Abstract

Background: Accumulating evidence suggest that dietary modification can lower the risk for several cancer types' development. Cranberry in particular, has been shown to have anti-oxidative, -inflammatory and -proliferative properties in vitro.

Objective: To present the latest knowledge regarding the role of cranberry extracts against human cancer several types.

Methods: A review of the literature documenting both in vitro and in vivo anti-cancer effects of whole cranberry and/or its extracts is conducted.

Conclusions: Current data provide evidence for several anti-cancer properties of either whole cranberry and/or its extracts. The discovery of the specific cranberry components and the appropriate concentrations that exert such beneficial effects along with verification of the preliminary in vitro results in in vivo settings could potentially lead to the invention of novel safer and efficient anti-cancer therapeutic agents.

Publication types

  • Review

MeSH terms

  • Anthocyanins / pharmacology
  • Anti-Inflammatory Agents, Non-Steroidal / chemistry
  • Anti-Inflammatory Agents, Non-Steroidal / isolation & purification
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / therapeutic use*
  • Antioxidants / chemistry
  • Antioxidants / isolation & purification
  • Antioxidants / therapeutic use
  • Apoptosis / drug effects
  • Cell Proliferation / drug effects
  • Flavonoids / pharmacology
  • Humans
  • Neoplasms / drug therapy*
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Oxidative Stress / drug effects
  • Plant Extracts / chemistry
  • Triterpenes / pharmacology
  • Ursolic Acid
  • Vaccinium macrocarpon / chemistry*

Substances

  • Anthocyanins
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antineoplastic Agents, Phytogenic
  • Antioxidants
  • Flavonoids
  • Plant Extracts
  • Triterpenes