Protective effects of passively transferred merozoite-specific antibodies against Theileria equi in horses with severe combined immunodeficiency

Clin Vaccine Immunol. 2012 Jan;19(1):100-4. doi: 10.1128/CVI.05301-11. Epub 2011 Oct 28.

Abstract

Theileria equi immune plasma was infused into young horses (foals) with severe combined immunodeficiency. Although all foals became infected following intravenous challenge with homologous T. equi merozoite stabilate, delayed time to peak parasitemia occurred. Protective effects were associated with a predominance of passively transferred merozoite-specific IgG3.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Antibodies, Protozoan / administration & dosage*
  • Antibodies, Protozoan / immunology
  • Horse Diseases / prevention & control*
  • Horse Diseases / therapy
  • Horses
  • Immunization, Passive / methods*
  • Immunoglobulin G / administration & dosage
  • Immunoglobulin G / immunology
  • Immunologic Factors / administration & dosage*
  • Immunologic Factors / immunology
  • Merozoites / immunology
  • Parasitemia / prevention & control
  • Severe Combined Immunodeficiency / veterinary*
  • Theileria / immunology
  • Theileriasis / prevention & control*
  • Time Factors

Substances

  • Antibodies, Protozoan
  • Immunoglobulin G
  • Immunologic Factors