Protective effects of Allium paradoxum against gentamicin-induced nephrotoxicity in mice

Food Funct. 2012 Jan;3(1):28-9. doi: 10.1039/c1fo10173k. Epub 2011 Oct 28.

Abstract

Allium paradoxum (M.Bieb.) G. Don is a locally known vegetable and is utilized for preparation a variety of local foods in northern of Iran. This study was conducted to quantitatively evaluate the recovery effects of A. paradoxum on gentamicin-induced nephrotoxicity in mice. The curative effect of extracts from the aerial parts and bulbs of A. paradoxum against gentamicin-induced renotoxicity in mice was determined. Both extracts at the dose 200 mg kg(-1) day(-1) offered nephroprotective effect by change in the blood urea nitrogen and creatinine. No statistical difference could be obtained in serum creatinine and blood urea nitrogen of bulb-treated mice compared to normal mice. The result show that bulb extract at 200 mg kg(-1) day(-1) has better activity than aerial parts.

MeSH terms

  • Allium / chemistry*
  • Animals
  • Disease Models, Animal
  • Gentamicins / toxicity*
  • Humans
  • Kidney Diseases / drug therapy*
  • Kidney Diseases / prevention & control*
  • Male
  • Mice
  • Plant Extracts / administration & dosage*

Substances

  • Gentamicins
  • Plant Extracts