The significant reduction of the cases of tetanus in the years led to an increased perception of risk associated with vaccination, which, like any medical procedure, entails the possibility of adverse reactions. Although the reviews of the literature show that the tetanus vaccine is implicated as responsible for serious adverse events, the neurological complications associated with it are extremely rare, as confirmed also by the small number of cases reported in the literature. It's necessary that all events temporally associated with vaccination are properly investigated and brought to the attention of healthcare workers and citizens, in order to establish an early treatment, which in most cases leads to complete recovery.