Abstract
The present study examined gender differences in response to methylphenidate (MPH) on energy intake and macronutrient preference. Twelve adults (6 men, 6 women) were given placebo or short-acting MPH (0.5 mg/kg) in a randomized, double blind, placebo-controlled crossover fashion. One hour after drug administration, appetite sensations and the relative reinforcing value of energy-dense snack food were measured, followed immediately by energy intake and macronutrient preference during a buffet lunch. Relative to placebo, men exhibited a significantly greater reduction in energy intake, fat intake, and carbohydrate intake after MPH administration compared with women. Future research is needed to verify these initial findings.
Publication types
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Clinical Trial
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Appetite / drug effects*
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Appetite Depressants / pharmacology*
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Appetite Depressants / therapeutic use
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Body Mass Index
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Central Nervous System Stimulants / pharmacology
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Central Nervous System Stimulants / therapeutic use
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Cross-Over Studies
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Dietary Carbohydrates / administration & dosage
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Dietary Fats / administration & dosage
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Dopamine Uptake Inhibitors / pharmacology*
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Dopamine Uptake Inhibitors / therapeutic use
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Double-Blind Method
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Energy Intake / drug effects*
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Female
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Food Preferences / drug effects
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Food Preferences / psychology
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Humans
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Male
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Methylphenidate / pharmacology*
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Methylphenidate / therapeutic use
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Overweight / drug therapy
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Overweight / psychology
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Pilot Projects
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Reinforcement, Psychology
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Sex Characteristics
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Young Adult
Substances
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Appetite Depressants
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Central Nervous System Stimulants
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Dietary Carbohydrates
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Dietary Fats
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Dopamine Uptake Inhibitors
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Methylphenidate