On using the bootstrap for multiple comparisons

J Biopharm Stat. 2011 Nov;21(6):1187-205. doi: 10.1080/10543406.2011.607751.

Abstract

There are many ways to bootstrap data for multiple comparisons procedures. Methods described here include (i) bootstrap (parametric and nonparametric) as a generalization of classical normal-based MaxT methods, (ii) bootstrap as an approximation to exact permutation methods, (iii) bootstrap as a generator of realistic null data sets, and (iv) bootstrap as a generator of realistic non-null data sets. Resampling of MinP versus MaxT is discussed, and the use of the bootstrap for closed testing is also presented. Applications to biopharmaceutical statistics are given.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Data Interpretation, Statistical*
  • Databases, Factual / statistics & numerical data*
  • Mice
  • Statistics, Nonparametric*