Importance of minimal residual viremia for relapse prediction in patients with chronic hepatitis C genotype 1 infection

Clin Infect Dis. 2011 Dec;53(11):1111-4. doi: 10.1093/cid/cir670. Epub 2011 Oct 21.

Abstract

This study demonstrates that a more precise prediction of the individual relapse risk in chronic hepatitis C virus genotype 1 infection can be obtained by kinetics of minimal residual viremia at weeks 4, 8, and 12 in combination with levels of baseline viremia. These data may also help to further individualize new protease inhibitor-based triple therapy regimens.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiviral Agents / administration & dosage
  • Genotype
  • Hepacivirus / classification
  • Hepacivirus / genetics
  • Hepacivirus / isolation & purification*
  • Hepatitis C, Chronic / drug therapy
  • Hepatitis C, Chronic / virology*
  • Humans
  • Interferon alpha-2
  • Interferon-alpha / administration & dosage
  • Polyethylene Glycols / administration & dosage
  • Recombinant Proteins / administration & dosage
  • Recurrence
  • Ribavirin / administration & dosage
  • Risk Assessment
  • Viral Load*
  • Viremia*

Substances

  • Antiviral Agents
  • Interferon alpha-2
  • Interferon-alpha
  • Recombinant Proteins
  • Polyethylene Glycols
  • Ribavirin
  • peginterferon alfa-2b