Abstract
Angiogenic markers in pituitary adenomas remain enigmatic in terms of their function in tumorigenesis, despite being upregulated by the normal physiological trigger of hypoxia. In this issue of Endocrine-Related Cancer, Shan et al. report that the novel RWD domain containing protein, RWD-containing sumoylation enhancer, is expressed in human pituitary adenomas and plays a pivotal role in regulating the hypoxia-inducible factor 1α-vascular endothelial growth factor response to hypoxia.
MeSH terms
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Adenoma / metabolism*
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Adenoma / pathology
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Animals
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Humans
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Hypoxia / metabolism*
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Hypoxia-Inducible Factor 1, alpha Subunit / metabolism
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Neovascularization, Pathologic
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Pituitary Neoplasms / metabolism*
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Pituitary Neoplasms / pathology
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Transcription Factors / metabolism
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Vascular Endothelial Growth Factor A / metabolism
Substances
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Hypoxia-Inducible Factor 1, alpha Subunit
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RWDD3 protein, human
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Transcription Factors
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VEGFA protein, human
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Vascular Endothelial Growth Factor A