Hypoxia-induced VEGF production 'RSUMEs' in pituitary adenomas

Endocr Relat Cancer. 2012 Jan 9;19(1):C1-5. doi: 10.1530/ERC-11-0297. Print 2012 Feb.

Abstract

Angiogenic markers in pituitary adenomas remain enigmatic in terms of their function in tumorigenesis, despite being upregulated by the normal physiological trigger of hypoxia. In this issue of Endocrine-Related Cancer, Shan et al. report that the novel RWD domain containing protein, RWD-containing sumoylation enhancer, is expressed in human pituitary adenomas and plays a pivotal role in regulating the hypoxia-inducible factor 1α-vascular endothelial growth factor response to hypoxia.

MeSH terms

  • Adenoma / metabolism*
  • Adenoma / pathology
  • Animals
  • Humans
  • Hypoxia / metabolism*
  • Hypoxia-Inducible Factor 1, alpha Subunit / metabolism
  • Neovascularization, Pathologic
  • Pituitary Neoplasms / metabolism*
  • Pituitary Neoplasms / pathology
  • Transcription Factors / metabolism
  • Vascular Endothelial Growth Factor A / metabolism

Substances

  • Hypoxia-Inducible Factor 1, alpha Subunit
  • RWDD3 protein, human
  • Transcription Factors
  • VEGFA protein, human
  • Vascular Endothelial Growth Factor A