Abstract
Floating-Harbor Syndrome (FHS) is a very rare condition of unknown etiology characterized by short stature, delayed bone age, characteristic facial features, delayed language skills and usually normal motor development. This syndrome has only once been associated with growth hormone deficiency and precocious puberty in the same patient. We describe a 5 4/12 year-old girl with the typical features of FHS in whom growth hormone deficiency was diagnosed and two years later central precocious puberty was noted. The patient showed a good response to human recombinant growth hormone as well as gonadotropin releasing hormone analogue treatment.
MeSH terms
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Abnormalities, Multiple / diagnosis*
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Abnormalities, Multiple / drug therapy
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Child
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Child, Preschool
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Craniofacial Abnormalities / complications
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Craniofacial Abnormalities / diagnosis*
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Craniofacial Abnormalities / drug therapy
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Diagnosis, Differential
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Dwarfism, Pituitary / diagnosis*
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Dwarfism, Pituitary / drug therapy
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Dwarfism, Pituitary / etiology
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Female
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Gonadotropin-Releasing Hormone / therapeutic use
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Growth Disorders / complications
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Growth Disorders / diagnosis*
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Growth Disorders / drug therapy
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Heart Septal Defects, Ventricular / complications
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Heart Septal Defects, Ventricular / diagnosis*
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Heart Septal Defects, Ventricular / drug therapy
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Human Growth Hormone / deficiency*
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Human Growth Hormone / therapeutic use
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Humans
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Puberty, Precocious / diagnosis
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Puberty, Precocious / drug therapy
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Puberty, Precocious / etiology
Substances
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Human Growth Hormone
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Gonadotropin-Releasing Hormone