It takes two to Get3

Irmgard Sinning; Gert Bange; Klemens Wild

doi:10.1016/j.str.2011.10.001

It takes two to Get3

Structure. 2011 Oct 12;19(10):1353-5. doi: 10.1016/j.str.2011.10.001.

Authors

Irmgard Sinning¹, Gert Bange, Klemens Wild

Affiliation

¹ Heidelberg University Biochemistry Center, INF 328, 69120 Heidelberg, Germany. irmi.sinning@bzh.uni-heidelberg

PMID: 22000508
DOI: 10.1016/j.str.2011.10.001

Abstract

Tail-anchored (TA) membrane proteins perform essential cellular functions. They are posttranslationally inserted into the endoplasmic reticulum (ER) membrane by interaction of the Get3 chaperone with the Get1/2 receptor. Two independent structural and functional analyses of the Get3/receptor complex by Stefer et al. and Mariappan et al. now provide insights into TA protein insertion.

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