Creatine supplementation does not augment muscle carnosine content in type 2 diabetic patients

Appl Physiol Nutr Metab. 2011 Oct;36(5):764-7. doi: 10.1139/h11-083.

Abstract

We examined whether creatine supplementation affects muscle carnosine content in type 2 diabetic patients. Subjects were randomly assigned to receive either creatine (5 g·day(-1)) or placebo in a double-blind fashion. At baseline and after 12 weeks, carnosine content was evaluated in gastrocnemius and soleus muscles by using a 1H-MRS technique. No changes were found in gastrocnemius (p = 0.81) and soleus (p = 0.85). We concluded that creatine supplementation does not augment muscle carnosine content in type 2 diabetic patients.

Trial registration: ClinicalTrials.gov NCT00992043.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Body Mass Index
  • Creatine / metabolism*
  • Diabetes Mellitus, Type 2 / metabolism*
  • Diabetes Mellitus, Type 2 / therapy
  • Dietary Supplements*
  • Double-Blind Method
  • Exercise
  • Female
  • Humans
  • Leg
  • Magnetic Resonance Spectroscopy
  • Male
  • Middle Aged
  • Muscle Fibers, Fast-Twitch / metabolism
  • Muscle Fibers, Slow-Twitch / metabolism
  • Muscle, Skeletal / metabolism*

Substances

  • Creatine

Associated data

  • ClinicalTrials.gov/NCT00992043