Development of a highly selective fluorescence probe for hydrogen sulfide

J Am Chem Soc. 2011 Nov 16;133(45):18003-5. doi: 10.1021/ja207851s. Epub 2011 Oct 25.

Abstract

Hydrogen sulfide (H(2)S) has recently been identified as a biological response modifier. Here, we report the design and synthesis of a novel fluorescence probe for H(2)S, HSip-1, utilizing azamacrocyclic copper(II) ion complex chemistry to control the fluorescence. HSip-1 showed high selectivity and high sensitivity for H(2)S, and its potential for biological applications was confirmed by employing it for fluorescence imaging of H(2)S in live cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Copper / chemistry*
  • Fluorescent Dyes / chemical synthesis
  • Fluorescent Dyes / chemistry*
  • HeLa Cells
  • Humans
  • Hydrogen Sulfide / analysis*
  • Hydrogen Sulfide / chemistry
  • Molecular Structure
  • Organometallic Compounds / chemical synthesis
  • Organometallic Compounds / chemistry*

Substances

  • Fluorescent Dyes
  • Organometallic Compounds
  • Copper
  • Hydrogen Sulfide