A plug and play polymeric template driven by supramolecular interactions

J Biomed Mater Res A. 2012 Jan;100(1):149-54. doi: 10.1002/jbm.a.33254. Epub 2011 Oct 14.

Abstract

A new "plug and play" polymeric template with the driving force of host-guest interaction between β-CD and naphthalene-modified functional groups was designed and studied. Multiple functional groups can be loaded into the template directly and conveniently. Importantly, the "plug and play" effect of the polymeric template is reversible and the functional groups could be removed from the polymeric template conveniently by adding AD-HCl. The studies on the cell viability and phagocytosis proved that the loading and unloading process of this template could be realized in vitro.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • COS Cells
  • Camptothecin / pharmacology
  • Cell Death / drug effects
  • Chlorocebus aethiops
  • Ethylenediamines / chemical synthesis
  • Ethylenediamines / chemistry
  • Ethylenediamines / pharmacology
  • HeLa Cells
  • Humans
  • Magnetic Resonance Spectroscopy
  • Microscopy, Confocal
  • Naphthaleneacetic Acids / chemical synthesis
  • Naphthaleneacetic Acids / chemistry
  • Naphthaleneacetic Acids / pharmacology
  • Oligopeptides / chemical synthesis
  • Oligopeptides / chemistry
  • Oligopeptides / pharmacology
  • Peptides / chemical synthesis
  • Peptides / chemistry
  • Peptides / pharmacology
  • Polymers / chemical synthesis*
  • Polymers / chemistry*
  • Polymers / pharmacology
  • Spectrometry, Fluorescence
  • beta-Cyclodextrins / chemical synthesis
  • beta-Cyclodextrins / chemistry
  • beta-Cyclodextrins / pharmacology

Substances

  • Ethylenediamines
  • Naphthaleneacetic Acids
  • Oligopeptides
  • Peptides
  • Polymers
  • beta-Cyclodextrins
  • polyaspartate
  • 2-naphthylacetic acid
  • arginyl-glycyl-aspartic acid
  • Camptothecin