Targeting heat shock response pathways to treat pancreatic cancer

Yi Xia; Palma Rocchi; Juan L Iovanna; Ling Peng

doi:10.1016/j.drudis.2011.09.016

Targeting heat shock response pathways to treat pancreatic cancer

Drug Discov Today. 2012 Jan;17(1-2):35-43. doi: 10.1016/j.drudis.2011.09.016. Epub 2011 Oct 1.

Authors

Yi Xia¹, Palma Rocchi, Juan L Iovanna, Ling Peng

Affiliation

¹ Centre Interdisciplinaire de Nanoscience de Marseille, Département de Chimie, CNRS UPR 3118, 163 Avenue de Luminy, 13288 Marseille, France.

PMID: 21986108
DOI: 10.1016/j.drudis.2011.09.016

Abstract

Pancreatic cancer belongs to the group of extremely aggressive human cancers; conventional cancer treatments have little impact. Increasing understanding of the pathways associated with pancreatic cancer progression has enabled the development of targeted therapy on this cancer. Heat shock proteins (HSPs) and related heat shock response (HSR) pathways control multiple important oncogenic pathways for pancreatic cancer development. Consequently, they represent promising novel targets for pancreatic cancer therapy. Various strategies have been proposed and elaborated to target HSPs/HSR in pancreatic cancer with the corresponding modulators, the details of which are highlighted in this review.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Drug Delivery Systems / methods
Heat-Shock Response / drug effects*
Humans
Pancreatic Neoplasms / drug therapy*
Pancreatic Neoplasms / metabolism
Signal Transduction / drug effects