Abstract
CD4+NKG2D+effector memory T-cell-mediated endothelial cell damage and a Th17 dominated cytokine profile of PR3-specific T-cells may play an important role in the pathogenesis of granulomatosis with polyangiitis (Wegener's). The anti-IL-5 antibody mepolizumab (anti-IL-5) induces remission in Churg-Strauss syndrome.
MeSH terms
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Animals
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Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / drug therapy
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Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / immunology*
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Antibodies, Monoclonal, Humanized / therapeutic use
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Autoimmune Diseases / drug therapy
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Autoimmune Diseases / immunology
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B-Lymphocyte Subsets / drug effects
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B-Lymphocyte Subsets / immunology*
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CD4-Positive T-Lymphocytes / drug effects
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CD4-Positive T-Lymphocytes / immunology
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Churg-Strauss Syndrome / drug therapy
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Churg-Strauss Syndrome / immunology
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Disease Models, Animal
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Endothelium, Vascular / drug effects
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Endothelium, Vascular / immunology
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Eosinophils / drug effects
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Eosinophils / immunology
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Glomerulonephritis / drug therapy
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Glomerulonephritis / immunology
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Granulocytes / drug effects
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Granulocytes / immunology
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Granulomatosis with Polyangiitis / drug therapy
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Granulomatosis with Polyangiitis / immunology
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Humans
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Immunologic Memory / immunology*
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Interleukin-5 / blood
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Mice
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NK Cell Lectin-Like Receptor Subfamily K / immunology
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Remission Induction
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T-Lymphocytes / drug effects
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T-Lymphocytes / immunology*
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Th17 Cells / drug effects
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Th17 Cells / immunology
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Th2 Cells / drug effects
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Th2 Cells / immunology
Substances
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Antibodies, Monoclonal, Humanized
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Interleukin-5
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KLRK1 protein, human
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NK Cell Lectin-Like Receptor Subfamily K
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mepolizumab