[T-cells in ANCA-associated vasculitis]

Z Rheumatol. 2011 Oct;70(8):698-700. doi: 10.1007/s00393-011-0780-z.
[Article in German]

Abstract

CD4+NKG2D+effector memory T-cell-mediated endothelial cell damage and a Th17 dominated cytokine profile of PR3-specific T-cells may play an important role in the pathogenesis of granulomatosis with polyangiitis (Wegener's). The anti-IL-5 antibody mepolizumab (anti-IL-5) induces remission in Churg-Strauss syndrome.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / drug therapy
  • Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / immunology*
  • Antibodies, Monoclonal, Humanized / therapeutic use
  • Autoimmune Diseases / drug therapy
  • Autoimmune Diseases / immunology
  • B-Lymphocyte Subsets / drug effects
  • B-Lymphocyte Subsets / immunology*
  • CD4-Positive T-Lymphocytes / drug effects
  • CD4-Positive T-Lymphocytes / immunology
  • Churg-Strauss Syndrome / drug therapy
  • Churg-Strauss Syndrome / immunology
  • Disease Models, Animal
  • Endothelium, Vascular / drug effects
  • Endothelium, Vascular / immunology
  • Eosinophils / drug effects
  • Eosinophils / immunology
  • Glomerulonephritis / drug therapy
  • Glomerulonephritis / immunology
  • Granulocytes / drug effects
  • Granulocytes / immunology
  • Granulomatosis with Polyangiitis / drug therapy
  • Granulomatosis with Polyangiitis / immunology
  • Humans
  • Immunologic Memory / immunology*
  • Interleukin-5 / blood
  • Mice
  • NK Cell Lectin-Like Receptor Subfamily K / immunology
  • Remission Induction
  • T-Lymphocytes / drug effects
  • T-Lymphocytes / immunology*
  • Th17 Cells / drug effects
  • Th17 Cells / immunology
  • Th2 Cells / drug effects
  • Th2 Cells / immunology

Substances

  • Antibodies, Monoclonal, Humanized
  • Interleukin-5
  • KLRK1 protein, human
  • NK Cell Lectin-Like Receptor Subfamily K
  • mepolizumab