A new furanoxanthone from the stem bark of Calophyllum inophyllum

Gwendoline Cheng Lian Ee; Siau Hui Mah; Mawardi Rahmani; Yun Hin Taufiq-Yap; Soek Sin Teh; Yang Mooi Lim

doi:10.1080/10286020.2011.600248

A new furanoxanthone from the stem bark of Calophyllum inophyllum

J Asian Nat Prod Res. 2011 Oct;13(10):956-60. doi: 10.1080/10286020.2011.600248.

Authors

Gwendoline Cheng Lian Ee¹, Siau Hui Mah, Mawardi Rahmani, Yun Hin Taufiq-Yap, Soek Sin Teh, Yang Mooi Lim

Affiliation

¹ Department of Chemistry, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. gwen@science.upm.edu.my

PMID: 21972812
DOI: 10.1080/10286020.2011.600248

Abstract

The stem bark extracts of Calophyllum inophyllum furnished one new furanoxanthone, inophinnin (1), in addition to inophyllin A (2), macluraxanthone (3), pyranojacareubin (4), 4-hydroxyxanthone, friedelin, stigmasterol, and betulinic acid. The structures of these compounds were determined by spectroscopic analysis of 1D and 2D NMR spectral data ((1)H, (13)C, DEPT, COSY, HMQC, and HMBC) while EI-MS gave the molecular mass. The new xanthone, inophinnin (1), exhibited some anti-inflammatory activity in nitric oxide assay.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anti-Inflammatory Agents, Non-Steroidal / chemistry
Anti-Inflammatory Agents, Non-Steroidal / isolation & purification*
Anti-Inflammatory Agents, Non-Steroidal / pharmacology
Calophyllum / chemistry*
Furans / chemistry
Furans / isolation & purification*
Furans / pharmacology
Malaysia
Mice
Molecular Structure
Plant Bark / chemistry
Xanthones / chemistry
Xanthones / isolation & purification*
Xanthones / pharmacology

Substances

Anti-Inflammatory Agents, Non-Steroidal
Furans
Xanthones
inophinnin