Three new compounds from soil actinomycete Streptomyces albospinus 15-4-2

J Asian Nat Prod Res. 2011 Oct;13(10):901-6. doi: 10.1080/10286020.2011.599322.

Abstract

Three new compounds, 2-methyl-2,5,6-bornantriol (1), 4,4'-(3-hydroxypropane-1,1-diyl)diphenol (2), and 7-(4-methoxybenzyl)-4,5,6,7-tetrahydro-1,3-oxazepine-5,6-diol (3), were isolated from the fermentation broth of the soil actinomycete Streptomyces albospinus 15-4-2. Their structures were completely elucidated using the combination of 1D, 2D NMR techniques (COSY, HMQC, HMBC, and ROESY), and HR-ESI-MS analysis. None of the compounds 1-3 showed any inhibitory effect on Fusarium oxysporum f.sp. cubense race 4.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents / chemistry
  • Antifungal Agents / isolation & purification*
  • Antifungal Agents / pharmacology
  • Camphanes / chemistry
  • Camphanes / isolation & purification*
  • Camphanes / pharmacology
  • China
  • Fusarium / drug effects
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Oxazepines / chemistry
  • Oxazepines / isolation & purification*
  • Oxazepines / pharmacology
  • Phenols / chemistry
  • Phenols / isolation & purification*
  • Phenols / pharmacology
  • Soil Microbiology*
  • Streptomyces / chemistry*

Substances

  • 2-methyl-2,5,6-bornantriol
  • 4,4'-(3-hydroxypropane-1,1-diyl)diphenol
  • 7-(4-methoxybenzyl)-4,5,6,7-tetrahydro-1,3-oxazepine-5,6-diol
  • Antifungal Agents
  • Camphanes
  • Oxazepines
  • Phenols