There is an urgent requirement for selecting appropriate technologies to solve food safety problems due to soil contamination. In this study, the hyperaccumulator Noccaea caerulescens and a high Cd accumulator pakchoi cultivar (Brassica rapa L. spp. Chinenesis cv.) were grown in a moderately Cd-contaminated soil with three planting systems (monocrop, inter-crop, and crop-rotation) and three growing durations (25, 50, and 75 days) to study the role of rhizosphere interaction of both species on the uptake of Cd. The Cd accumulations in the shoot of pakchoi were significantly reduced in the inter-crop treatment, also the decreased percentage increased with rhizosphere interaction between the two species. In the inter-crop systems of 75 days, the Cd concentration and amount in the shoot of pakchoi represented 54% and 83% reduction, respectively, while the total depletion of Cd decreased by approximate 19%. Although the Cd concentration and amount in the shoot of pakchoi were significantly reduced by 52% and 44%, respectively, in the crop-rotation treatment, the decreased percentage were markedly lower than in the inter-crop treatment. Therefore, the rhizosphere interaction of hyperaccumulator with non-hyperaccumulator may reduce the risk of vegetable contamination during making full use of or remediating the contaminated soil.