Pregnancy associated pyogenic granuloma of the oral cavity especially the gingivae is not uncommon. However, pyogenic granuloma of the lip associated with pregnancy is a very rare clinical condition. A case of a 29 year-old pregnant woman (35 weeks gestation) who presented with a pregnancy associated pyogenic granuloma of the lower lip is reported. Chronic irritation of the lower lip which acts in an unidentified way with high gingival level of active progesterone is the suspected pathogenesis. Surgical excision was the treatment of choice, and no recurrence was noted.