Abstract
Two new polyketides, arthropsadiol C (1) and massarilactone H (2), together with six known derivatives (3-8) were isolated from the culture broth of the marine-derived fungus Phoma herbarum. Their structures were elucidated on the basis of spectroscopic methods, including 2D NMR techniques. Compounds 2, 4, 5, and 8 showed moderate neuraminidase inhibitory activity with IC(50) values ranging from 4.15 to 9.16 µM.
© Georg Thieme Verlag KG Stuttgart · New York.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Ascomycota / chemistry*
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Biological Products / chemistry
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Biological Products / pharmacology*
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / isolation & purification
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Enzyme Inhibitors / pharmacology*
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Molecular Structure
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Neuraminidase / antagonists & inhibitors*
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Polyketides / chemistry
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Polyketides / isolation & purification
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Polyketides / pharmacology*
Substances
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Biological Products
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Enzyme Inhibitors
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Polyketides
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arthropsadiol C
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massarilactone H
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Neuraminidase