Neuraminidase inhibitory polyketides from the marine-derived fungus Phoma herbarum

Planta Med. 2012 Jan;78(1):76-8. doi: 10.1055/s-0031-1280251. Epub 2011 Sep 27.

Abstract

Two new polyketides, arthropsadiol C (1) and massarilactone H (2), together with six known derivatives (3-8) were isolated from the culture broth of the marine-derived fungus Phoma herbarum. Their structures were elucidated on the basis of spectroscopic methods, including 2D NMR techniques. Compounds 2, 4, 5, and 8 showed moderate neuraminidase inhibitory activity with IC(50) values ranging from 4.15 to 9.16 µM.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Ascomycota / chemistry*
  • Biological Products / chemistry
  • Biological Products / pharmacology*
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / isolation & purification
  • Enzyme Inhibitors / pharmacology*
  • Molecular Structure
  • Neuraminidase / antagonists & inhibitors*
  • Polyketides / chemistry
  • Polyketides / isolation & purification
  • Polyketides / pharmacology*

Substances

  • Biological Products
  • Enzyme Inhibitors
  • Polyketides
  • arthropsadiol C
  • massarilactone H
  • Neuraminidase