PLA/ β-TCP complex tubes: the mechanical properties and applications of artificial bone

J Biomater Sci Polym Ed. 2012;23(13):1701-12. doi: 10.1163/092050611X597762. Epub 2012 May 8.

Abstract

Poly(lactic acid) (PLA) twisted yarn was braided into a 6-layered, hollow, cylindrical braid on a 16-spindle braid machine. The PLA braid was then placed inside a β-TCP tube, forming the PLA/β-TCP complex tube which imitates the porous structure of sponge bone. Different components and structures were studied to determine the best bone molding material. The β-TCP tube was created by sintering TCP powder mixed with stearic acid in a ratio of 1:1.5 to form a highly porous and well-structured tube with interconnected pores; its resulting porosity was 85.8 ± 0.93%. The PLA/β-TCP complex tube was implanted in a rabbit's femur and after 3 months a marrow cavity was discovered at the tube's core. New bone was also observed, regenerating around the PLA braid within the PLA/β-TCP complex tube.

Keywords: 16-spindle braid machine; MG-63; complex tubes; poly(lactic acid); β-TCP.

MeSH terms

  • Animals
  • Bone Regeneration / physiology
  • Bone Substitutes* / chemistry
  • Calcium Phosphates* / chemistry
  • Cell Line, Tumor
  • Cell Survival
  • Coculture Techniques
  • Disease Models, Animal
  • Femur / injuries
  • Femur / pathology
  • Femur / physiopathology
  • Humans
  • Lactic Acid* / chemistry
  • Materials Testing
  • Microscopy, Electron, Scanning
  • Polyesters
  • Polymers* / chemistry
  • Porosity
  • Rabbits
  • Stearic Acids / chemistry
  • Tissue Engineering / instrumentation
  • Tissue Engineering / methods

Substances

  • Bone Substitutes
  • Calcium Phosphates
  • Polyesters
  • Polymers
  • Stearic Acids
  • beta-tricalcium phosphate
  • Lactic Acid
  • poly(lactide)
  • stearic acid