Acute and long-term safety of external trigeminal nerve stimulation for drug-resistant epilepsy

Juliana Pop; Diana Murray; Daniela Markovic; Christopher M DeGiorgio

doi:10.1016/j.yebeh.2011.06.024

Acute and long-term safety of external trigeminal nerve stimulation for drug-resistant epilepsy

Epilepsy Behav. 2011 Nov;22(3):574-6. doi: 10.1016/j.yebeh.2011.06.024. Epub 2011 Sep 29.

Authors

Juliana Pop¹, Diana Murray, Daniela Markovic, Christopher M DeGiorgio

Affiliation

¹ Department of Neurology, Olive View Internal Medicine Program, UCLA School of Medicine, Los Angeles, CA 90095, USA.

PMID: 21959083
DOI: 10.1016/j.yebeh.2011.06.024

Abstract

Trigeminal nerve stimulation (TNS) is a novel therapy for drug-resistant epilepsy. We report in detail the safety of external TNS (eTNS), focusing on acute and long-term heart rate and systolic and diastolic blood pressure in response to TNS from the pilot feasibility study. The data indicate that eTNS of the infraorbital and supraorbital branches of the trigeminal nerve is safe and well tolerated.

Publication types

Clinical Trial
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Aged
Analysis of Variance
Blood Pressure / physiology
Electric Stimulation Therapy / methods*
Epilepsy / therapy*
Follow-Up Studies
Heart Rate / physiology
Humans
Middle Aged
Time Factors
Trigeminal Nerve / physiology*
Young Adult