[Effect of Eupolyphaga fibrinolytic protein on microvessel density and the expression of vascular endothelial growth factor in mice tumor]

Zhong Yao Cai. 2011 May;34(5):676-9.
[Article in Chinese]

Abstract

Objective: To study the effect of Eupolyphaga fibrinolyric protein (EFP) on microvessel density (MVD) and the expression of vascular endthelial growth factor in transplantation S180 and H22 mice.

Methods: The MVD in tumor was measured with immunohistochemical SP method and the VEGF level in serum was measured with ELISA method.

Results: Compared with the control group, EFP could significantly reduce the microvessel density and decrease the expression of vascular endothelial growth factor.

Conclusion: EFP has the effect of anti-angiogenesis.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiogenesis Inhibitors / pharmacology*
  • Animals
  • Antigens, CD34 / metabolism
  • Carcinoma, Hepatocellular / blood supply
  • Carcinoma, Hepatocellular / metabolism
  • Carcinoma, Hepatocellular / pathology
  • Cell Line, Tumor
  • Cockroaches* / chemistry
  • Dose-Response Relationship, Drug
  • Endothelial Cells / metabolism
  • Female
  • Immunohistochemistry
  • Insect Proteins / pharmacology*
  • Liver Neoplasms / blood supply
  • Liver Neoplasms / metabolism*
  • Liver Neoplasms / pathology*
  • Male
  • Mice
  • Microvessels / pathology
  • Neoplasm Transplantation
  • Neovascularization, Pathologic*
  • Sarcoma 180 / blood supply
  • Sarcoma 180 / metabolism
  • Sarcoma 180 / pathology
  • Vascular Endothelial Growth Factor A / blood*
  • Vascular Endothelial Growth Factor A / metabolism

Substances

  • Angiogenesis Inhibitors
  • Antigens, CD34
  • Insect Proteins
  • Vascular Endothelial Growth Factor A