Abstract
Objective:
To study the effect of Eupolyphaga fibrinolyric protein (EFP) on microvessel density (MVD) and the expression of vascular endthelial growth factor in transplantation S180 and H22 mice.
Methods:
The MVD in tumor was measured with immunohistochemical SP method and the VEGF level in serum was measured with ELISA method.
Results:
Compared with the control group, EFP could significantly reduce the microvessel density and decrease the expression of vascular endothelial growth factor.
Conclusion:
EFP has the effect of anti-angiogenesis.
Publication types
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English Abstract
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Research Support, Non-U.S. Gov't
MeSH terms
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Angiogenesis Inhibitors / pharmacology*
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Animals
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Antigens, CD34 / metabolism
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Carcinoma, Hepatocellular / blood supply
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Carcinoma, Hepatocellular / metabolism
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Carcinoma, Hepatocellular / pathology
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Cell Line, Tumor
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Cockroaches* / chemistry
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Dose-Response Relationship, Drug
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Endothelial Cells / metabolism
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Female
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Immunohistochemistry
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Insect Proteins / pharmacology*
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Liver Neoplasms / blood supply
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Liver Neoplasms / metabolism*
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Liver Neoplasms / pathology*
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Male
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Mice
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Microvessels / pathology
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Neoplasm Transplantation
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Neovascularization, Pathologic*
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Sarcoma 180 / blood supply
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Sarcoma 180 / metabolism
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Sarcoma 180 / pathology
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Vascular Endothelial Growth Factor A / blood*
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Vascular Endothelial Growth Factor A / metabolism
Substances
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Angiogenesis Inhibitors
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Antigens, CD34
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Insect Proteins
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Vascular Endothelial Growth Factor A