Study of the incorporation and release of the non-conventional half-sandwich ruthenium(II) metallodrug RAPTA-C on a robust MOF

Elsa Quartapelle Procopio; Sara Rojas; Natalia M Padial; Simona Galli; Norberto Masciocchi; Fátima Linares; Delia Miguel; J Enrique Oltra; Jorge A R Navarro; Elisa Barea

doi:10.1039/c1cc14594k

Study of the incorporation and release of the non-conventional half-sandwich ruthenium(II) metallodrug RAPTA-C on a robust MOF

Chem Commun (Camb). 2011 Nov 14;47(42):11751-3. doi: 10.1039/c1cc14594k. Epub 2011 Sep 28.

Authors

Elsa Quartapelle Procopio¹, Sara Rojas, Natalia M Padial, Simona Galli, Norberto Masciocchi, Fátima Linares, Delia Miguel, J Enrique Oltra, Jorge A R Navarro, Elisa Barea

Affiliation

¹ Universidad de Granada, Departamento de Química Inorganica, 18071 Granada, Spain.

PMID: 21952589
DOI: 10.1039/c1cc14594k

Abstract

The highly porous and robust [Ni(8)(OH)(4)(OH(2))(2)(4,4'-(buta-1,3-diyne-1,4-diyl)bispyrazolato)(6)](n) MOF can be used as a proof of concept for the incorporation and release of the non-conventional [Ru(p-cymene)Cl(2)(pta)] RAPTA-C metallodrug.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemistry*
Cymenes
Organometallic Compounds / chemistry*
Ruthenium / chemistry*

Substances

Antineoplastic Agents
Cymenes
Organometallic Compounds
dichloro(4-cymene)(1,3,5-triaza-7-phosphatricyclo(3.3.1.1)decane)ruthenium(II)
Ruthenium