Genomic analysis at the single-cell level

Tomer Kalisky; Paul Blainey; Stephen R Quake

doi:10.1146/annurev-genet-102209-163607

Genomic analysis at the single-cell level

Annu Rev Genet. 2011:45:431-45. doi: 10.1146/annurev-genet-102209-163607. Epub 2011 Sep 19.

Authors

Tomer Kalisky¹, Paul Blainey, Stephen R Quake

Affiliation

¹ Department of Bioengineering, Stanford University and Howard Hughes Medical Institute, Stanford, California 94305, USA. quake@stanford.edu

PMID: 21942365
PMCID: PMC3878048
DOI: 10.1146/annurev-genet-102209-163607

Abstract

Studying complex biological systems such as a developing embryo, a tumor, or a microbial ecosystem often involves understanding the behavior and heterogeneity of the individual cells that constitute the system and their interactions. In this review, we discuss a variety of approaches to single-cell genomic analysis.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Cells / cytology*
Flow Cytometry
Genomics / methods*
High-Throughput Screening Assays
Humans
Microscopy
Polymerase Chain Reaction / methods
Sequence Analysis, RNA
Single-Cell Analysis / instrumentation*
Single-Cell Analysis / methods*
Tissue Array Analysis

Grants and funding

HHMI/Howard Hughes Medical Institute/United States