Abstract
Efficient procedures for the synthesis of benzo-fluorinated dibenz[b,f]azepines (iminostilbenes) from fluorinated isatins or indoles using a number of ring-expansion reactions are described. A range of mono- and difluorinated analogues is accessible, and the syntheses can deliver gram quantities of the final products, which are precursors of fluoro analogues of the important anticonvulsant carbamazepine.
© 2011 American Chemical Society
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acridines / chemistry*
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Anticonvulsants / chemical synthesis
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Anticonvulsants / chemistry
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Azepines / chemical synthesis*
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Azepines / chemistry
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Carbamazepine / analogs & derivatives
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Carbamazepine / chemical synthesis
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Carbamazepine / chemistry
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Catalysis
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Hydrocarbons, Fluorinated / chemical synthesis*
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Hydrocarbons, Fluorinated / chemistry*
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Indoles / chemistry*
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Isatin / analogs & derivatives*
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Isatin / chemistry*
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Molecular Structure
Substances
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Acridines
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Anticonvulsants
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Azepines
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Hydrocarbons, Fluorinated
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Indoles
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Carbamazepine
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Isatin