Abstract
(S)- and (R)-BIMBOL were efficient PT catalysts of asymmetric Michael addition of prochiral Ni-PBP-Gly (1) to acrylic esters and malonic esters to Ni-PBP-Δ-Ala (2) correspondingly. The salient feature of the catalysis is opposite configurations of Glu prepared via the two paths with BIMBOL of the same configuration and a perspective novel catalytic procedure for the synthesis of Gla derivatives.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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1-Carboxyglutamic Acid / chemistry
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Alanine / analogs & derivatives
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Alanine / chemistry
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Catalysis
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Glutamic Acid / chemistry*
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Glycine / chemistry
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Naphthols / chemistry*
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Naphthols / metabolism
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Nickel / chemistry
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Schiff Bases / chemistry*
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Stereoisomerism
Substances
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Naphthols
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Schiff Bases
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Glutamic Acid
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1-Carboxyglutamic Acid
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Nickel
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dehydroalanine
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Alanine
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Glycine