Clinical laboratory implementation of cytogenomic microarrays

S T South; A R Brothman

doi:10.1159/000331425

Clinical laboratory implementation of cytogenomic microarrays

Cytogenet Genome Res. 2011;135(3-4):203-11. doi: 10.1159/000331425. Epub 2011 Sep 16.

Authors

S T South¹, A R Brothman

Affiliation

¹ Department of Pediatrics, ARUP Institute for Clinical and Experimental Pathology, ARUP Laboratories, University of Utah School of Medicine, Salt Lake City, Utah, USA.

PMID: 21934287
DOI: 10.1159/000331425

Abstract

Examination of the whole genome for copy number alterations by microarray is now routinely done in many laboratories. The field of cytogenetics has evolved to adapt this technology, and the current phase of transition has resulted in the need for standardization in methodologies and interpretation of data. This review will outline some of the changes addressed in the field over the last several years and briefly discuss some of the trends in data processing, analysis and interpretation.

Publication types

Review

MeSH terms

Animals
Comparative Genomic Hybridization / methods*
Comparative Genomic Hybridization / standards
Cytogenetic Analysis / methods
Cytogenetic Analysis / standards
DNA Copy Number Variations
Data Interpretation, Statistical
Gene Dosage
Genome-Wide Association Study
Humans
Oligonucleotide Array Sequence Analysis / methods*
Oligonucleotide Array Sequence Analysis / standards
Polymorphism, Single Nucleotide
Reproducibility of Results
Software