Abstract
A catalytic amount of Hantzsch ester that could be regenerated in situ by Ru complexes under hydrogen gas has been employed in the biomimetic asymmetric hydrogenation of benzoxazinones with up to 99% ee in the presence of chiral phosphoric acid. The use of hydrogen gas as a reductant for the regeneration of Hantzsch esters makes this hydrogenation an ideal atom economic process.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Benzoxazines / chemistry*
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Biomimetic Materials / chemical synthesis*
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Biomimetic Materials / chemistry
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Catalysis
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Esters / chemical synthesis*
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Esters / chemistry
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Hydrogen / chemistry*
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Hydrogenation
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Molecular Structure
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Organometallic Compounds / chemistry
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Ruthenium / chemistry
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Stereoisomerism
Substances
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Benzoxazines
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Esters
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Organometallic Compounds
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Ruthenium
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Hydrogen