Quinolone induction of qnrVS1 in Vibrio splendidus and plasmid-carried qnrS1 in Escherichia coli, a mechanism independent of the SOS system

Antimicrob Agents Chemother. 2011 Dec;55(12):5942-5. doi: 10.1128/AAC.05142-11. Epub 2011 Sep 19.

Abstract

Plasmid-carried qnrS1 is derived from Vibrio splendidus chromosomal qnrVS1. qnrVS1 transcripts increased 21- to 34-fold with subinhibitory concentrations of ciprofloxacin but much less with mitomycin. No LexA binding sites were upstream of qnrS1 or qnrVS1, and similar induction levels were observed in lexA-positive and lexA-negative Escherichia coli strains with native qnrS1 plasmid pMG306 but not with pUC18-cloned qnrS1 or qnrVS1. Thus, qnrS1 induction by quinolones is independent of the SOS system and requires sequence besides that of the structural gene.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Bacterial Proteins / drug effects*
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism
  • Ciprofloxacin / pharmacology
  • Drug Resistance, Bacterial / genetics
  • Escherichia coli / drug effects
  • Escherichia coli Proteins / drug effects*
  • Escherichia coli Proteins / genetics
  • Escherichia coli Proteins / metabolism
  • Humans
  • Microbial Sensitivity Tests
  • Mitomycin / pharmacology
  • Plasmids / genetics*
  • Quinolones / pharmacology*
  • SOS Response, Genetics / drug effects*
  • Vibrio / drug effects*
  • Vibrio / genetics

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Escherichia coli Proteins
  • Qnr protein, E coli
  • Quinolones
  • Mitomycin
  • Ciprofloxacin