Abstract
Plasmid-carried qnrS1 is derived from Vibrio splendidus chromosomal qnrVS1. qnrVS1 transcripts increased 21- to 34-fold with subinhibitory concentrations of ciprofloxacin but much less with mitomycin. No LexA binding sites were upstream of qnrS1 or qnrVS1, and similar induction levels were observed in lexA-positive and lexA-negative Escherichia coli strains with native qnrS1 plasmid pMG306 but not with pUC18-cloned qnrS1 or qnrVS1. Thus, qnrS1 induction by quinolones is independent of the SOS system and requires sequence besides that of the structural gene.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Bacterial Proteins / drug effects*
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism
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Ciprofloxacin / pharmacology
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Drug Resistance, Bacterial / genetics
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Escherichia coli / drug effects
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Escherichia coli Proteins / drug effects*
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Escherichia coli Proteins / genetics
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Escherichia coli Proteins / metabolism
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Humans
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Microbial Sensitivity Tests
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Mitomycin / pharmacology
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Plasmids / genetics*
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Quinolones / pharmacology*
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SOS Response, Genetics / drug effects*
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Vibrio / drug effects*
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Vibrio / genetics
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Escherichia coli Proteins
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Qnr protein, E coli
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Quinolones
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Mitomycin
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Ciprofloxacin