Genetic features of CTX-M-15-producing Acinetobacter baumannii from Haiti

Anaïs Potron; L Silvia Munoz-Price; Patrice Nordmann; Timothy Cleary; Laurent Poirel

doi:10.1128/AAC.05124-11

Genetic features of CTX-M-15-producing Acinetobacter baumannii from Haiti

Antimicrob Agents Chemother. 2011 Dec;55(12):5946-8. doi: 10.1128/AAC.05124-11. Epub 2011 Sep 19.

Authors

Anaïs Potron¹, L Silvia Munoz-Price, Patrice Nordmann, Timothy Cleary, Laurent Poirel

Affiliation

¹ Service de Bactériologie-Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine et Université Paris-Sud, Le Kremlin-Bicêtre Cedex, France.

Abstract

Acinetobacter baumannii isolates T23, W35, and H1 were isolated from three patients who had been injured in the Haiti earthquake in January 2010. Those isolates, corresponding to two distinct clones, were identified as extended-spectrum β-lactamase (ESBL) producers and found to be bla(CTX-M-15)-positive. That ESBL gene was associated with ISEcp1, involved in its acquisition by a one-ended transposition mechanism. In all isolates, the ISEcp1-bla(CTX-M-15) compound transposon was apparently chromosomally located.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acinetobacter Infections / epidemiology
Acinetobacter Infections / microbiology*
Acinetobacter baumannii / enzymology
Acinetobacter baumannii / genetics*
Bacterial Typing Techniques
DNA Transposable Elements / genetics
DNA, Bacterial / genetics
Earthquakes
Haiti / epidemiology
Humans
Microbial Sensitivity Tests
Molecular Sequence Data
Sequence Analysis, DNA
beta-Lactamases / biosynthesis*
beta-Lactamases / genetics*

Substances

DNA Transposable Elements
DNA, Bacterial
beta-lactamase CTX-M-15
beta-Lactamases

Associated data

GENBANK/JN788266
GENBANK/JN788267