Abstract
The Toll-interacting protein (Tollip) is a critical regulator of Toll-like receptor (TLR)-mediated innate immune responses. Tollip modulates TLR signaling and membrane trafficking processes through its interaction with both proteins and phosphoinositides. Here, I discuss the multitasking role of Tollip associated with its modular architecture.
Copyright © 2011 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Humans
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Immunity, Innate*
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Intracellular Signaling Peptides and Proteins / chemistry
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Intracellular Signaling Peptides and Proteins / immunology
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Intracellular Signaling Peptides and Proteins / metabolism*
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Phosphatidylinositols / metabolism
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Protein Binding
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Protein Transport*
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Signal Transduction
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Toll-Like Receptors / immunology
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Toll-Like Receptors / metabolism*
Substances
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Intracellular Signaling Peptides and Proteins
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Phosphatidylinositols
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TOLLIP protein, human
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Toll-Like Receptors