Tollip: a multitasking protein in innate immunity and protein trafficking

Microbes Infect. 2012 Feb;14(2):140-7. doi: 10.1016/j.micinf.2011.08.018. Epub 2011 Sep 8.

Abstract

The Toll-interacting protein (Tollip) is a critical regulator of Toll-like receptor (TLR)-mediated innate immune responses. Tollip modulates TLR signaling and membrane trafficking processes through its interaction with both proteins and phosphoinositides. Here, I discuss the multitasking role of Tollip associated with its modular architecture.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Humans
  • Immunity, Innate*
  • Intracellular Signaling Peptides and Proteins / chemistry
  • Intracellular Signaling Peptides and Proteins / immunology
  • Intracellular Signaling Peptides and Proteins / metabolism*
  • Phosphatidylinositols / metabolism
  • Protein Binding
  • Protein Transport*
  • Signal Transduction
  • Toll-Like Receptors / immunology
  • Toll-Like Receptors / metabolism*

Substances

  • Intracellular Signaling Peptides and Proteins
  • Phosphatidylinositols
  • TOLLIP protein, human
  • Toll-Like Receptors