Luminescent ruthenium(II) polypyridyl functionalized gold nanoparticles; their DNA binding abilities and application as cellular imaging agents

J Am Chem Soc. 2011 Oct 12;133(40):15862-5. doi: 10.1021/ja2061159. Epub 2011 Sep 20.

Abstract

The synthesis and photophysical and biological investigation of Ru(II)-polypyridyl stabilized water-soluble, luminescent gold nanoparticles (AuNPs) are described. These structures bind to DNA and undergo rapid cellular uptake, being localized within the cell cytoplasm and nucleus within 4 h.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Nucleus / ultrastructure
  • Cytoplasm / ultrastructure
  • DNA / metabolism*
  • Gold / analysis
  • Gold / chemistry*
  • HeLa Cells
  • Humans
  • Luminescence
  • Luminescent Agents / analysis*
  • Luminescent Agents / chemistry
  • Microscopy, Confocal / methods
  • Nanoparticles / analysis*
  • Nanoparticles / chemistry
  • Nanoparticles / ultrastructure
  • Organometallic Compounds / analysis*
  • Organometallic Compounds / chemistry
  • Pyridines / analysis*
  • Pyridines / chemistry
  • Pyridines / metabolism

Substances

  • Luminescent Agents
  • Organometallic Compounds
  • Pyridines
  • Gold
  • DNA