Biyoulactones A-C, new pentacyclic meroterpenoids from Hypericum chinense

Org Lett. 2011 Oct 21;13(20):5488-91. doi: 10.1021/ol2021548. Epub 2011 Sep 16.

Abstract

Three novel pentacyclic meroterpenoids with a unique dilactone structure containing C-C bonded bi- and tricyclic γ-lactone moieties, biyoulactones A-C (1-3), were isolated from the roots of Hypericum chinense, and their structures were elucidated on the basis of spectroscopic data. The relative and absolute stereochemistry of 1 was assigned by a combination of NOESY and a single crystal X-ray diffraction analysis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Crystallography, X-Ray
  • Drug Screening Assays, Antitumor
  • Humans
  • Hypericum / chemistry*
  • KB Cells
  • Molecular Conformation
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Plant Roots / chemistry
  • Plants, Medicinal / chemistry*
  • Terpenes / chemistry
  • Terpenes / isolation & purification*
  • Terpenes / pharmacology

Substances

  • Antineoplastic Agents, Phytogenic
  • Terpenes
  • biyoulactone A
  • biyoulactone B
  • biyoulactone C