Abstract
Three novel pentacyclic meroterpenoids with a unique dilactone structure containing C-C bonded bi- and tricyclic γ-lactone moieties, biyoulactones A-C (1-3), were isolated from the roots of Hypericum chinense, and their structures were elucidated on the basis of spectroscopic data. The relative and absolute stereochemistry of 1 was assigned by a combination of NOESY and a single crystal X-ray diffraction analysis.
© 2011 American Chemical Society
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Crystallography, X-Ray
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Drug Screening Assays, Antitumor
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Humans
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Hypericum / chemistry*
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KB Cells
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Molecular Conformation
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plant Roots / chemistry
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Plants, Medicinal / chemistry*
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Terpenes / chemistry
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Terpenes / isolation & purification*
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Terpenes / pharmacology
Substances
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Antineoplastic Agents, Phytogenic
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Terpenes
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biyoulactone A
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biyoulactone B
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biyoulactone C