Abstract
A hydroxamate siderophore, neoaspergillic acid (1), and a red pigment, ferrineoaspergillin (2) which is an Fe(III) complex of 1, were produced by co-cultures of two epiphytic fungi from a rotten fruit of the mangrove Avicennia marina from the South China Sea, and a new Cu(II) complex of 1, designated as cuprineoaspergillin (3), was also prepared by treatment of 1 with cupric acetate. All the compounds (1-3) were characterized by physical and chemical techniques, including 1H NMR, ESIMS, and photoelectron energy spectra. In the bioassays, compounds 1-3 showed significant inhibitory activities against selected Gram-positive and Gram-negative bacteria, and compound 1 also exhibited moderate inhibitory activities against human cancer cell lines SPC-A-1, BEL-7402, SGC-7901 and K562.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / metabolism
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Antineoplastic Agents / pharmacology
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Avicennia / microbiology*
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Cell Line, Tumor
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Coculture Techniques
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Copper / chemistry*
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Copper / metabolism
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Copper / pharmacology
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Ferric Compounds / chemistry*
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Ferric Compounds / metabolism
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Ferric Compounds / pharmacology
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Fruit / microbiology
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Fusarium / metabolism
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Humans
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Iron / chemistry*
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Iron / metabolism
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Iron / pharmacology
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Organometallic Compounds / chemistry*
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Organometallic Compounds / metabolism
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Organometallic Compounds / pharmacology
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Pyrazines / chemistry*
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Pyrazines / metabolism
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Pyrazines / pharmacology
Substances
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Antineoplastic Agents
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Ferric Compounds
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Organometallic Compounds
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Pyrazines
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cuprineoaspergillin
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ferrineoaspergillin
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aspergillic acid
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Copper
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Iron